Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Notch signaling plays an important role in several cellular functions including growth, differentiation, cell fate determination and stemness. Increased Notch activity has been linked to several types of cancers. Activation of Notch signaling is triggered by the interaction of Notch receptors (Notch...

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Detalles Bibliográficos
Autores principales: Platonova, Natalia, Parravicini, Chiara, Sensi, Cristina, Paoli, Alessandro, Colombo, Michela, Neri, Antonino, Eberini, Ivano, Chiaramonte, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669421/
https://www.ncbi.nlm.nih.gov/pubmed/29099834
http://dx.doi.org/10.1371/journal.pone.0182640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669421/
https://www.ncbi.nlm.nih.gov/pubmed/29099834
http://dx.doi.org/10.1371/journal.pone.0182640

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