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Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening
Notch signaling plays an important role in several cellular functions including growth, differentiation, cell fate determination and stemness. Increased Notch activity has been linked to several types of cancers. Activation of Notch signaling is triggered by the interaction of Notch receptors (Notch...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669421/ https://www.ncbi.nlm.nih.gov/pubmed/29099834 http://dx.doi.org/10.1371/journal.pone.0182640 |