Zn(2+) chelation by serum albumin improves hexameric Zn(2+)-insulin dissociation into monomers after exocytosis

β-cells release hexameric Zn(2+)-insulin into the extracellular space, but monomeric Zn(2+)-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn(2+) concentration-dependent. In this study, we inv...

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Detalles Bibliográficos
Autores principales: Pertusa, José A. G., León-Quinto, Trinidad, Berná, Genoveva, Tejedo, Juan R., Hmadcha, Abdelkrim, Bedoya, Francisco J., Martín, Franz, Soria, Bernat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669427/
https://www.ncbi.nlm.nih.gov/pubmed/29099856
http://dx.doi.org/10.1371/journal.pone.0187547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669427/
https://www.ncbi.nlm.nih.gov/pubmed/29099856
http://dx.doi.org/10.1371/journal.pone.0187547

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