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Zn(2+) chelation by serum albumin improves hexameric Zn(2+)-insulin dissociation into monomers after exocytosis
β-cells release hexameric Zn(2+)-insulin into the extracellular space, but monomeric Zn(2+)-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn(2+) concentration-dependent. In this study, we inv...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669427/ https://www.ncbi.nlm.nih.gov/pubmed/29099856 http://dx.doi.org/10.1371/journal.pone.0187547 |