Structure-based pKa prediction provides a thermodynamic basis for the role of histidines in pH-induced conformational transitions in dengue virus

pH-induced conformational changes in dengue virus (DENV) are critical to its ability to infect host cells. The envelope protein heterodimers that make up the viral envelope shift from a dimer to a trimer conformation at low-pH during membrane fusion. Previous studies have suggested that the ionizati...

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Detalles Bibliográficos
Autores principales: Chaudhury, Sidhartha, Ripoll, Daniel R., Wallqvist, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669449/
https://www.ncbi.nlm.nih.gov/pubmed/29124227
http://dx.doi.org/10.1016/j.bbrep.2015.10.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669449/
https://www.ncbi.nlm.nih.gov/pubmed/29124227
http://dx.doi.org/10.1016/j.bbrep.2015.10.014

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