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Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2) activities by siastatin B and structural prediction of NEU2/siastatin B complex

Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates. The effect of siastatin B, known as a sialidase inhibitor, has not been evaluated toward human NEU2 yet. We studied the regulation of NEU2 activity by siastatin B in vitro a...

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Detalles Bibliográficos
Autores principales: Rahman, M. Motiur, Hirokawa, Takatsugu, Tsuji, Daisuke, Tsukimoto, Jun, Hitaoka, Seiji, Yoshida, Tatsusada, Chuman, Hiroshi, Itoh, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669518/
https://www.ncbi.nlm.nih.gov/pubmed/29124209
http://dx.doi.org/10.1016/j.bbrep.2015.09.017