CDK9-dependent RNA polymerase II pausing controls transcription initiation

Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a ‘multi-omics’ approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency...

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Detalles Bibliográficos
Autores principales: Gressel, Saskia, Schwalb, Björn, Decker, Tim Michael, Qin, Weihua, Leonhardt, Heinrich, Eick, Dirk, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669633/
https://www.ncbi.nlm.nih.gov/pubmed/28994650
http://dx.doi.org/10.7554/eLife.29736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669633/
https://www.ncbi.nlm.nih.gov/pubmed/28994650
http://dx.doi.org/10.7554/eLife.29736

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