PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma

Cell line models of the activated B cell-like (ABC) subtype of diffuse large B cell (DLBCL) depend on both NF-κB and phosphatidylinositol 3-kinase (PI3K) signaling pathways for survival, especially those with gain-of-function B cell receptor (BCR) mutations. Here we show that these cells depend spec...

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Detalles Bibliográficos
Autores principales: Pongas, Georgios N., Annunziata, Christina M., Staudt, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669848/
https://www.ncbi.nlm.nih.gov/pubmed/29137222
http://dx.doi.org/10.18632/oncotarget.20864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669848/
https://www.ncbi.nlm.nih.gov/pubmed/29137222
http://dx.doi.org/10.18632/oncotarget.20864

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