Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells

Obesity is involved in tumor progression. However, the corresponding mechanisms remain largely unknown. Here, we report that adipocytes increase the invasive ability of tumor cells by producing exosomes with a high level of MMP3. Compared with 3T3-L1 cells, 3T3-L1 adipocytes are enriched in MMP3 pro...

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Detalles Bibliográficos
Autores principales: Wang, Jiaoli, Wu, Yilei, Guo, Jufeng, Fei, Xuefeng, Yu, Lei, Ma, Shenglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669856/
https://www.ncbi.nlm.nih.gov/pubmed/29137230
http://dx.doi.org/10.18632/oncotarget.18737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669856/
https://www.ncbi.nlm.nih.gov/pubmed/29137230
http://dx.doi.org/10.18632/oncotarget.18737

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