The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34(+) cells

The translocation t(4;11)(q21;q23) is the hallmark genetic abnormality associated with infant pro-B acute lymphoblastic leukemia (B-ALL) and has the highest frequency of rearrangement in Mixed-lineage leukemia (MLL) leukemias. Unlike other MLL translocations, MLL-AF4-induced proB-ALL is exceptionall...

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Detalles Bibliográficos
Autores principales: Prieto, Cristina, Marschalek, Rolf, Kühn, Alessa, Bursen, Adelheid, Bueno, Clara, Menéndez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669860/
https://www.ncbi.nlm.nih.gov/pubmed/29137234
http://dx.doi.org/10.18632/oncotarget.19567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669860/
https://www.ncbi.nlm.nih.gov/pubmed/29137234
http://dx.doi.org/10.18632/oncotarget.19567

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