Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer’s disease

The intramembrane proteolytic activities of presenilins (PSEN1/PS1 and PSEN2/PS2) underlie production of β-amyloid, the key process in Alzheimer’s disease (AD). Dysregulation of presenilin-mediated signaling is linked to cancers. Inhibition of the γ-cleavage activities of PSENs that produce Aβ, but...

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Detalles Bibliográficos
Autores principales: Grigorenko, Anastasia P., Moliaka, Youri K., Plotnikova, Olga V., Smirnov, Alexander, Nikishina, Vera A., Goltsov, Andrey Y., Gusev, Fedor, Andreeva, Tatiana V., Nelson, Omar, Bezprozvanny, Ilya, Rogaev, Evgeny I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669866/
https://www.ncbi.nlm.nih.gov/pubmed/29137240
http://dx.doi.org/10.18632/oncotarget.18299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669866/
https://www.ncbi.nlm.nih.gov/pubmed/29137240
http://dx.doi.org/10.18632/oncotarget.18299

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