Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, in the case of breast cancer patients, this phenomenon correlated with high expression level...

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Detalles Bibliográficos
Autores principales: Tracz-Gaszewska, Zuzanna, Klimczak, Marta, Biecek, Przemyslaw, Herok, Marcin, Kosinski, Marcin, Olszewski, Maciej B., Czerwińska, Patrycja, Wiech, Milena, Wiznerowicz, Maciej, Zylicz, Alicja, Zylicz, Maciej, Wawrzynow, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669876/
https://www.ncbi.nlm.nih.gov/pubmed/29137250
http://dx.doi.org/10.18632/oncotarget.18899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669876/
https://www.ncbi.nlm.nih.gov/pubmed/29137250
http://dx.doi.org/10.18632/oncotarget.18899

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