Probably less than one-tenth of the genes produce only the wild type protein without at least one additional protein isoform in some human cancer cell lines

To estimate how many genes produce multiple protein isoforms, we electrophoresed proteins from MCF7 and MDA-MB231 (MB231) human breast cancer cells in SDS-PAGE and excised narrow stripes of the gel at the 48kD, 55kD and 72kD. Proteins in these stripes were identified using liquid chromatography and...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Rui, Zhang, Ju, Zellmer, Lucas, Chen, Lichan, Wu, Di, Liu, Siqi, Xu, Ningzhi, Liao, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669923/
https://www.ncbi.nlm.nih.gov/pubmed/29137297
http://dx.doi.org/10.18632/oncotarget.20015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669923/
https://www.ncbi.nlm.nih.gov/pubmed/29137297
http://dx.doi.org/10.18632/oncotarget.20015

Ejemplares similares