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Probably less than one-tenth of the genes produce only the wild type protein without at least one additional protein isoform in some human cancer cell lines
To estimate how many genes produce multiple protein isoforms, we electrophoresed proteins from MCF7 and MDA-MB231 (MB231) human breast cancer cells in SDS-PAGE and excised narrow stripes of the gel at the 48kD, 55kD and 72kD. Proteins in these stripes were identified using liquid chromatography and...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669923/ https://www.ncbi.nlm.nih.gov/pubmed/29137297 http://dx.doi.org/10.18632/oncotarget.20015 |