Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

B7x (B7-H4 or B7S1) is a coinhibitory member of the B7 immune checkpoint ligand family that regulates immune function following ligation with its unknown cognate receptors. B7x has limited expression on normal tissues, but is up-regulated on solid human tumors to inhibit anti-tumor immunity and asso...

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Detalles Bibliográficos
Autores principales: Ohaegbulam, Kim C., Liu, Weifeng, Jeon, Hyungjun, Almo, Steven C., Zang, Xingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669925/
https://www.ncbi.nlm.nih.gov/pubmed/29137299
http://dx.doi.org/10.18632/oncotarget.21098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669925/
https://www.ncbi.nlm.nih.gov/pubmed/29137299
http://dx.doi.org/10.18632/oncotarget.21098

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