Cargando…

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

B7x (B7-H4 or B7S1) is a coinhibitory member of the B7 immune checkpoint ligand family that regulates immune function following ligation with its unknown cognate receptors. B7x has limited expression on normal tissues, but is up-regulated on solid human tumors to inhibit anti-tumor immunity and asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohaegbulam, Kim C., Liu, Weifeng, Jeon, Hyungjun, Almo, Steven C., Zang, Xingxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669925/ https://www.ncbi.nlm.nih.gov/pubmed/29137299 http://dx.doi.org/10.18632/oncotarget.21098

Ejemplares similares

B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
por: Jeon, Hyungjun, et al.
Publicado: (2013)

The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy
por: John, Peter, et al.
Publicado: (2022)

The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic T Lymphocyte Exhaustion
por: Hofmeyer, Kimberly A., et al.
Publicado: (2011)

Immune checkpoints on innate lymphoid cells
por: Chiossone, Laura, et al.
Publicado: (2017)

Dead cell phagocytosis and innate immune checkpoint
por: Yoon, Kyoung Wan
Publicado: (2017)

Immune Checkpoint Molecules and Glucose Metabolism in HIV-Induced T Cell Exhaustion
por: Chan, Yee Teng, et al.
Publicado: (2022)

Regulation of the innate immune cells during pregnancy: An immune checkpoint perspective
por: Li, Wen‐Xuan, et al.
Publicado: (2021)

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
por: Wang, Hao, et al.
Publicado: (2019)

Is CD47 an innate immune checkpoint for tumor evasion?
por: Liu, Xiaojuan, et al.
Publicado: (2017)

Tumor fitness, immune exhaustion and clinical outcomes: impact of immune checkpoint inhibitors
por: Bubie, Adrian, et al.
Publicado: (2020)

Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease
Publicado: (2022)

Immune Checkpoints and Innate Lymphoid Cells—New Avenues for Cancer Immunotherapy
por: Jacquelot, Nicolas, et al.
Publicado: (2021)

Do adaptive immune cells suppress or activate innate immunity?
por: Zhao, Jie, et al.
Publicado: (2009)

Oxidation of Innate Immune Checkpoint CD47 on Cancer Cells with Non-Thermal Plasma
por: Lin, Abraham, et al.
Publicado: (2021)

Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
por: Saleh, Reem, et al.
Publicado: (2020)

Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer
por: Stromnes, Ingunn M, et al.
Publicado: (2022)

Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
por: Bronte, Giuseppe, et al.
Publicado: (2021)

Suppression of CEBPδ recovers exhaustion in anti-metastatic immune cells
por: Yin, Chenxue, et al.
Publicado: (2023)

Innate-like T cells straddle innate and adaptive immunity by revising antigen-receptor responsiveness
por: Wencker, Melanie, et al.
Publicado: (2013)

2018 Nobel Prize in medicine awarded to cancer immunotherapy: Immune checkpoint blockade – A personal account
por: Zang, Xingxing
Publicado: (2018)

Structure and functions of Mer, an innate immune checkpoint
por: Ubil, Eric, et al.
Publicado: (2023)

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells
por: Viramontes, Karla M., et al.
Publicado: (2022)

Hierarchical transcriptional network governing heterogeneous T cell exhaustion and its implications for immune checkpoint blockade
por: Tian, Weihong, et al.
Publicado: (2023)

Type 17 immunity promotes the exhaustion of CD8(+) T cells in cancer
por: Kim, Byung-Seok, et al.
Publicado: (2021)

Pretreatment Innate Cell Populations and CD4 T Cells in Blood Are Associated With Response to Immune Checkpoint Blockade in Melanoma Patients
por: Pirozyan, Mehdi R., et al.
Publicado: (2020)

Innate immune checkpoints for cancer immunotherapy: expanding the scope of non T cell targets
por: Campesato, Luis F., et al.
Publicado: (2020)

Alterations in the innate immune system due to exhausting exercise in intensively trained rats
por: Estruel-Amades, Sheila, et al.
Publicado: (2020)

Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response
por: McGoverne, Isabella, et al.
Publicado: (2020)

TLR2 – an innate immune checkpoint in multiple sclerosis
por: Hossain, Md Jakir, et al.
Publicado: (2015)

Cancer Immunotherapy by Blocking Immune Checkpoints on Innate Lymphocytes
por: Pesce, Silvia, et al.
Publicado: (2020)

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy
por: Wick, Maresa, et al.
Publicado: (1997)

Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus
por: Zapała, Łukasz, et al.
Publicado: (2022)

Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen
por: Fan, Shengtao, et al.
Publicado: (2019)

Targeting immune checkpoint pathways overcomes tumor-induced CD8+ T cell suppression
por: Pfannenstiel, Lukas W, et al.
Publicado: (2014)

Targeting KIT on innate immune cells enhances the antitumor activity of checkpoint inhibitors in vivo
por: Gedrich, Richard, et al.
Publicado: (2015)

Modeling tumor immunity of mouse glioblastoma by exhausted CD8(+) T cells
por: Nakashima, Hiroshi, et al.
Publicado: (2018)

Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis
por: Hu, Jinyang, et al.
Publicado: (2020)

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8(+) T-cell activation and exhaustion
por: Belizário, José, et al.
Publicado: (2020)

Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities
por: Haas, Quentin, et al.
Publicado: (2022)

Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia
por: Morgan, David J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vpmlmajgc59lodfaofa6sha8tf