Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to compl...

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Detalles Bibliográficos
Autores principales: Yu, J, Chen, L, Chen, Y, Hasan, M K, Ghia, E M, Zhang, L, Wu, R, Rassenti, L Z, Widhopf, G F, Shen, Z, Briggs, S P, Kipps, T J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670032/
https://www.ncbi.nlm.nih.gov/pubmed/28465528
http://dx.doi.org/10.1038/leu.2017.132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670032/
https://www.ncbi.nlm.nih.gov/pubmed/28465528
http://dx.doi.org/10.1038/leu.2017.132

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