Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the nucleotide-substrate-binding and catalytic sites. Conventional,...

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Detalles Bibliográficos
Autores principales: Dulin, David, Arnold, Jamie J., van Laar, Theo, Oh, Hyung-Suk, Lee, Cheri, Perkins, Angela L., Harki, Daniel A., Depken, Martin, Cameron, Craig E., Dekker, Nynke H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670035/
https://www.ncbi.nlm.nih.gov/pubmed/29069588
http://dx.doi.org/10.1016/j.celrep.2017.10.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670035/
https://www.ncbi.nlm.nih.gov/pubmed/29069588
http://dx.doi.org/10.1016/j.celrep.2017.10.005

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