CRISPR interference-guided multiplex repression of endogenous competing pathway genes for redirecting metabolic flux in Escherichia coli

BACKGROUND: Multiplex control of metabolic pathway genes is essential for maximizing product titers and conversion yields of fuels, chemicals, and pharmaceuticals in metabolic engineering. To achieve this goal, artificial transcriptional regulators, such as clustered regularly interspaced short pali...

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Detalles Bibliográficos
Autores principales: Kim, Seong Keun, Seong, Wonjae, Han, Gui Hwan, Lee, Dae-Hee, Lee, Seung-Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Technical Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670510/
https://www.ncbi.nlm.nih.gov/pubmed/29100516
http://dx.doi.org/10.1186/s12934-017-0802-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670510/
https://www.ncbi.nlm.nih.gov/pubmed/29100516
http://dx.doi.org/10.1186/s12934-017-0802-x

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