Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

BACKGROUND: Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration. METHODS: Here, we overexpress various genet...

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Detalles Bibliográficos
Autores principales: Bobela, Wojciech, Nazeeruddin, Sameer, Knott, Graham, Aebischer, Patrick, Schneider, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670705/
https://www.ncbi.nlm.nih.gov/pubmed/29100525
http://dx.doi.org/10.1186/s13024-017-0220-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670705/
https://www.ncbi.nlm.nih.gov/pubmed/29100525
http://dx.doi.org/10.1186/s13024-017-0220-x

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