Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

Slow and continuous release of H(2)S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells. The resulting lactate overproduction and defective pH homeostas...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Zheng-Wei, Teo, Xin-Yi, Song, Zhi J., Nin, Dawn S., Novera, Wisna, Choo, Bok A., Dymock, Brian W., Moore, Philip K., Huang, Ruby Y.-J., Deng, Lih-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671507/
https://www.ncbi.nlm.nih.gov/pubmed/29163155
http://dx.doi.org/10.3389/fphar.2017.00763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671507/
https://www.ncbi.nlm.nih.gov/pubmed/29163155
http://dx.doi.org/10.3389/fphar.2017.00763

Ejemplares similares