Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells

RAS signalling is involved in the control of several metabolic pathways including glycolysis, mitochondrial respiration and glutamine metabolism. Importantly, we have found here that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell growth inhibition in tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Trinidad, A G, Whalley, N, Rowlinson, R, Delpuech, O, Dudley, P, Rooney, C, Critchlow, S E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671936/
https://www.ncbi.nlm.nih.gov/pubmed/28692044
http://dx.doi.org/10.1038/onc.2017.224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671936/
https://www.ncbi.nlm.nih.gov/pubmed/28692044
http://dx.doi.org/10.1038/onc.2017.224

Ejemplares similares