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Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
RAS signalling is involved in the control of several metabolic pathways including glycolysis, mitochondrial respiration and glutamine metabolism. Importantly, we have found here that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell growth inhibition in tum...
Autores principales: | Trinidad, A G, Whalley, N, Rowlinson, R, Delpuech, O, Dudley, P, Rooney, C, Critchlow, S E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671936/ https://www.ncbi.nlm.nih.gov/pubmed/28692044 http://dx.doi.org/10.1038/onc.2017.224 |
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