A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer

BACKGROUND: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. METHODS: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate monoclonal antibodies (MAbs), which were...

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Detalles Bibliográficos
Autores principales: O'Sullivan, Dermot, Dowling, Paul, Joyce, Helena, McAuley, Edel, McCann, Andrew, Henry, Michael, McGovern, Brianan, Barham, Paul, Kelleher, Fergal C, Murphy, Jean, Kennedy, Susan, Swan, Niall, Moriarty, Michael, Clynes, Martin, Larkin, Annemarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672937/
https://www.ncbi.nlm.nih.gov/pubmed/28881357
http://dx.doi.org/10.1038/bjc.2017.306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672937/
https://www.ncbi.nlm.nih.gov/pubmed/28881357
http://dx.doi.org/10.1038/bjc.2017.306

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