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A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity
Redesigning protein surface topology to improve target binding holds great promise in the search for highly selective therapeutics. While significant binding improvements can be achieved using natural amino acids, the introduction of non-canonical residues vastly increases sequence space and thus th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673230/ https://www.ncbi.nlm.nih.gov/pubmed/29108013 http://dx.doi.org/10.1371/journal.pone.0187524 |