The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung

Locked nucleic acid containing antisense oligonucleotides (LNA-ASOs) have the potential to modulate the disease-related gene expression by the RNaseH-dependent degradation of mRNAs. Pulmonary drug delivery has been widely used for the treatment of lung disease. Thus, the inhalation of LNA-ASOs is ex...

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Detalles Bibliográficos
Autores principales: Uemura, Yasunori, Hagiwara, Kenji, Kobayashi, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673232/
https://www.ncbi.nlm.nih.gov/pubmed/29107995
http://dx.doi.org/10.1371/journal.pone.0187286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673232/
https://www.ncbi.nlm.nih.gov/pubmed/29107995
http://dx.doi.org/10.1371/journal.pone.0187286

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