Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding of a neurotransmitter. Despite the increasing availability of high-resolution structures of pLGICs, a detailed understanding of the functional i...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin, Nicolas E, Malik, Siddharth, Calimet, Nicolas, Changeux, Jean-Pierre, Cecchini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673239/
https://www.ncbi.nlm.nih.gov/pubmed/29069080
http://dx.doi.org/10.1371/journal.pcbi.1005784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673239/
https://www.ncbi.nlm.nih.gov/pubmed/29069080
http://dx.doi.org/10.1371/journal.pcbi.1005784

Ejemplares similares