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The downregulation of ATG4B mediated by microRNA-34a/34c-5p suppresses rapamycin-induced autophagy

OBJECTIVE(S): Autophagy-related 4B (ATG4B) plays an important role in the process of autophagy induction. However, the molecular events that govern the expression of ATG4B in this process are not well known. MATERIALS AND METHODS: Human ATG4B 3’-UTR region (1377 nt) containing miR-34a/miR-34c-5p bin...

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Detalles Bibliográficos
Autores principales: Wu, Yaran, Dai, Xufang, Ni, Zhenhong, Yan, Xiaojing, He, Fengtian, Lian, Jiqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673697/
https://www.ncbi.nlm.nih.gov/pubmed/29147488
http://dx.doi.org/10.22038/IJBMS.2017.9446