Cargando…

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromoso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jäkel, Cornelia, Bergmann, Frank, Toth, Reka, Assenov, Yassen, van der Duin, Daniel, Strobel, Oliver, Hank, Thomas, Klöppel, Günter, Dorrell, Craig, Grompe, Markus, Moss, Joshua, Dor, Yuval, Schirmacher, Peter, Plass, Christoph, Popanda, Odilia, Schmezer, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673892/ https://www.ncbi.nlm.nih.gov/pubmed/29109526 http://dx.doi.org/10.1038/s41467-017-01118-x

Ejemplares similares

Diacylglycerol Kinase Alpha in Radiation-Induced Fibrosis: Potential as a Predictive Marker or Therapeutic Target
por: Liu, Chun-Shan, et al.
Publicado: (2020)

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
por: Weigel, Christoph, et al.
Publicado: (2016)

Enrichment analysis with EpiAnnotator
por: Pageaud, Yoann, et al.
Publicado: (2018)

Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response
por: Liu, Chun-Shan, et al.
Publicado: (2021)

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma
por: Goeppert, Benjamin, et al.
Publicado: (2019)

Molecular analysis of pancreatic acinar cell cystadenomas: Evidence of a non-neoplastic nature
por: BERGMANN, FRANK, et al.
Publicado: (2014)

Maftools: efficient and comprehensive analysis of somatic variants in cancer
por: Mayakonda, Anand, et al.
Publicado: (2018)

Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis
por: Goeppert, Benjamin, et al.
Publicado: (2022)

DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
por: Weigel, Christoph, et al.
Publicado: (2019)

ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition
por: Bakr, Ali, et al.
Publicado: (2021)

Random forest-based modelling to detect biomarkers for prostate cancer progression
por: Toth, Reka, et al.
Publicado: (2019)

Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML
por: Islam, Mirazul, et al.
Publicado: (2017)

The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis
por: Zhou, Xiaodong, et al.
Publicado: (2017)

TRPM4 links calcium signaling to membrane potential in pancreatic acinar cells
por: Diszházi, Gyula, et al.
Publicado: (2021)

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
por: Bernhardt, Mathias, et al.
Publicado: (2017)

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells
por: Schamschula, Esther, et al.
Publicado: (2021)

Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway
por: Sakikubo, Morito, et al.
Publicado: (2018)

Comprehensive Analysis of DNA Methylation Data with RnBeads
por: Assenov, Yassen, et al.
Publicado: (2014)

Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL
por: Wierzbinska, Justyna A., et al.
Publicado: (2020)

Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies
por: Greve, Burkhard, et al.
Publicado: (2012)

Acinar Cell Cystadenoma (Acinar Cystic Transformation) of the Pancreas: the Radiologic-Pathologic Features
por: Gumus, Mehmet, et al.
Publicado: (2011)

RnBeads 2.0: comprehensive analysis of DNA methylation data
por: Müller, Fabian, et al.
Publicado: (2019)

Maintenance of Acinar Cell Organization is Critical to Preventing Kras-Induced Acinar-Ductal Metaplasia
por: Shi, Guanglu, et al.
Publicado: (2012)

TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells
por: Liu, Jun, et al.
Publicado: (2016)

Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis
por: Gu, H, et al.
Publicado: (2013)

Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
por: Li, Bin, et al.
Publicado: (2017)

Acinar Cell Cystadenocarcinoma of the Pancreas
por: Aoto, Keita, et al.
Publicado: (2017)

Pancreatic Acinar Cell Carcinoma
por: Béchade, Dominique, et al.
Publicado: (2016)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS)
por: Faltus, Christian, et al.
Publicado: (2022)

Pancreatic Ductal Bicarbonate Secretion: Challenge of the Acinar Acid Load
por: Hegyi, Péter, et al.
Publicado: (2011)

Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer
por: Chang-Claude, J, et al.
Publicado: (2009)

Luteolin inhibits pancreatitis-induced acinar-ductal metaplasia, proliferation and epithelial-mesenchymal transition of acinar cells
por: Huang, Xince, et al.
Publicado: (2018)

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature
por: Zundler, Sebastian, et al.
Publicado: (2016)

Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer
por: Liou, Geou-Yarh, et al.
Publicado: (2015)

Human islets contain four distinct subtypes of β cells
por: Dorrell, Craig, et al.
Publicado: (2016)

LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis
por: Lehle, Simon, et al.
Publicado: (2014)

Regulated Exocytosis in the Pancreatic Acinar Cell
por: Jamieson, J.D., et al.
Publicado: (1997)

Discussion: Pancreatic Acinar Cell Pathophysiology
por: Gorelick, Fred S.
Publicado: (1992)

SULFATE METABOLISM IN PANCREATIC ACINAR CELLS
por: Berg, Norton B., et al.
Publicado: (1971)

Cannot write session to /tmp/vufind_sessions/sess_lck843a3820qge2i4938rl7rlh