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Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism

The neuroectoderm is patterned along a rostral-caudal axis in response to localized factors in the embryo, but exactly how these factors act as positional information for this patterning is not yet fully understood. Here, using the self-organizing properties of mouse embryonic stem cell (ESC), we re...

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Detalles Bibliográficos
Autores principales: Takata, Nozomu, Sakakura, Eriko, Eiraku, Mototsugu, Kasukawa, Takeya, Sasai, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673904/
https://www.ncbi.nlm.nih.gov/pubmed/29109536
http://dx.doi.org/10.1038/s41467-017-01105-2