Oral Apolipoprotein A‐I Mimetic D‐4F Lowers HDL‐Inflammatory Index in High‐Risk Patients: A First‐in‐Human Multiple‐Dose, Randomized Controlled Trial

A single dose of the apolipoprotein (apo)A‐I mimetic peptide D‐4F rendered high‐density lipoprotein (HDL) less inflammatory, motivating the first multiple‐dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily, orally administered D‐4F. High‐risk coronary...

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Detalles Bibliográficos
Autores principales: Dunbar, Richard L., Movva, Rajesh, Bloedon, LeAnne T., Duffy, Danielle, Norris, Robert B., Navab, Mohamad, Fogelman, Alan M., Rader, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673907/
https://www.ncbi.nlm.nih.gov/pubmed/28795506
http://dx.doi.org/10.1111/cts.12487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673907/
https://www.ncbi.nlm.nih.gov/pubmed/28795506
http://dx.doi.org/10.1111/cts.12487

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