Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum

Familial Alzheimer’s disease (AD) is caused by mutations in the genes that encode amyloid precursor protein (APP) and presenilins. Disturbances in calcium homeostasis have been observed in various cellular and animal models of AD and are proposed to underlie the pathogenesis of the disease. Furtherm...

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Detalles Bibliográficos
Autores principales: Gazda, Kinga, Kuznicki, Jacek, Wegierski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673940/
https://www.ncbi.nlm.nih.gov/pubmed/29109429
http://dx.doi.org/10.1038/s41598-017-15166-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673940/
https://www.ncbi.nlm.nih.gov/pubmed/29109429
http://dx.doi.org/10.1038/s41598-017-15166-2

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