Cargando…
Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum
Familial Alzheimer’s disease (AD) is caused by mutations in the genes that encode amyloid precursor protein (APP) and presenilins. Disturbances in calcium homeostasis have been observed in various cellular and animal models of AD and are proposed to underlie the pathogenesis of the disease. Furtherm...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673940/ https://www.ncbi.nlm.nih.gov/pubmed/29109429 http://dx.doi.org/10.1038/s41598-017-15166-2 |