Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum l‐asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes

Rhodospirillum rubrum L‐asparaginase mutant (E149R, V150P, F151T) (RrA) down‐regulates telomerase activity due to its ability to inhibit the expression of telomerase catalytic subunit hTERT. The aim of this study was to define the effect of short‐term and long‐term RrA exposure on proliferation of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhdanov, Dmitry D., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Eldarov, Mikhail A., Grishin, Dmitry V., Basharov, Marsel M., Gladilina, Yulia A., Podobed, Olga V., Sokolov, Nikolai N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673955/
https://www.ncbi.nlm.nih.gov/pubmed/28984046
http://dx.doi.org/10.1002/cam4.1218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673955/
https://www.ncbi.nlm.nih.gov/pubmed/28984046
http://dx.doi.org/10.1002/cam4.1218

Ejemplares similares