Cargando…

Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum l‐asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes

Rhodospirillum rubrum L‐asparaginase mutant (E149R, V150P, F151T) (RrA) down‐regulates telomerase activity due to its ability to inhibit the expression of telomerase catalytic subunit hTERT. The aim of this study was to define the effect of short‐term and long‐term RrA exposure on proliferation of c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhdanov, Dmitry D., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Eldarov, Mikhail A., Grishin, Dmitry V., Basharov, Marsel M., Gladilina, Yulia A., Podobed, Olga V., Sokolov, Nikolai N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673955/ https://www.ncbi.nlm.nih.gov/pubmed/28984046 http://dx.doi.org/10.1002/cam4.1218

Ejemplares similares

Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase
por: Plyasova, Anna A., et al.
Publicado: (2020)

Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from Rhodospirillum rubrum by Conjugation with Chitosan-Based Cationic Polyelectrolytes
por: Dobryakova, Natalia V., et al.
Publicado: (2022)

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions
por: Pokrovskaya, Marina V., et al.
Publicado: (2022)

Highly Active Thermophilic L-Asparaginase from Melioribacter roseus Represents a Novel Large Group of Type II Bacterial L-Asparaginases from Chlorobi-Ignavibacteriae-Bacteroidetes Clade
por: Dumina, Maria, et al.
Publicado: (2021)

The Structure of Rhodospirillum rubrum
por: Hickman, Donald D., et al.
Publicado: (1959)

Engineering and Expression Strategies for Optimization of L-Asparaginase Development and Production
por: Shishparenok, Anastasiya N., et al.
Publicado: (2023)

A Novel L-Asparaginase from Hyperthermophilic Archaeon Thermococcus sibiricus: Heterologous Expression and Characterization for Biotechnology Application
por: Dumina, Maria, et al.
Publicado: (2021)

THE FINE STRUCTURE OF RHODOSPIRILLUM RUBRUM
por: Cohen-Bazire, Germaine, et al.
Publicado: (1963)

OBSERVATIONS ON THE STRUCTURE OF RHODOSPIRILLUM RUBRUM
por: Hickman, Donald D., et al.
Publicado: (1965)

OBSERVATIONS ON THE FINE STRUCTURE OF SPHEROPLASTS OF RHODOSPIRILLUM RUBRUM
por: Boatman, E. S.
Publicado: (1964)

Enhancing the Catalytic Activity of Thermo-Asparaginase from Thermococcus sibiricus by a Double Mesophilic-like Mutation in the Substrate-Binding Region
por: Dumina, Maria, et al.
Publicado: (2023)

Complete genome sequence of Rhodospirillum rubrum type strain (S1(T))
por: Munk, A. Christine, et al.
Publicado: (2011)

Temperature dependence of photosynthetic reaction centre activity in Rhodospirillum rubrum
por: Kaftan, David, et al.
Publicado: (2019)

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases
por: Pokrovsky, Vadim S., et al.
Publicado: (2016)

Structure and Photochemical Activity of Chlorophyll-Containing Particles from Rhodospirillum rubrum
por: Frenkel, Albert W., et al.
Publicado: (1959)

Investigation of candidate genes involved in the rhodoquinone biosynthetic pathway in Rhodospirillum rubrum
por: Campbell, Amanda R. M., et al.
Publicado: (2019)

Analysis of the Involvement of the Isoleucine Biosynthesis Pathway in Photoheterotrophic Metabolism of Rhodospirillum rubrum
por: Bayon-Vicente, Guillaume, et al.
Publicado: (2021)

Metabolic Regulation as a Consequence of Anaerobic 5-Methylthioadenosine Recycling in Rhodospirillum rubrum
por: North, Justin A., et al.
Publicado: (2016)

Syngas obtained by microwave pyrolysis of household wastes as feedstock for polyhydroxyalkanoate production in Rhodospirillum rubrum
por: Revelles, Olga, et al.
Publicado: (2016)

Application of static and impulse magnetic fields to bacteria Rhodospirillum rubrum VKM B-1621
por: Khokhlova, Galina, et al.
Publicado: (2017)

New perspectives on butyrate assimilation in Rhodospirillum rubrum S1H under photoheterotrophic conditions
por: De Meur, Quentin, et al.
Publicado: (2020)

Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å
por: Qian, Pu, et al.
Publicado: (2021)

H(+)-Translocating Membrane-Bound Pyrophosphatase from Rhodospirillum rubrum Fuels Escherichia coli Cells via an Alternative Pathway for Energy Generation
por: Malykh, Evgeniya A., et al.
Publicado: (2023)

Quorum sensing influences growth and photosynthetic membrane production in high-cell-density cultivations of Rhodospirillum rubrum
por: Carius, Lisa, et al.
Publicado: (2013)

Energy shifts induce membrane sequestration of DraG in Rhodospirillum rubrum independent of the ammonium transporters and diazotrophic conditions
por: Wang, Helen, et al.
Publicado: (2018)

Tailor‐made PAT platform for safe syngas fermentations in batch, fed‐batch and chemostat mode with Rhodospirillum rubrum
por: Karmann, Stephanie, et al.
Publicado: (2017)

Enhancement of biohydrogen production rate in Rhodospirillum rubrum by a dynamic CO-feeding strategy using dark fermentation
por: Rodríguez, Alberto, et al.
Publicado: (2021)

Effects of Mixing Volatile Fatty Acids as Carbon Sources on Rhodospirillum rubrum Carbon Metabolism and Redox Balance Mechanisms
por: Cabecas Segura, Paloma, et al.
Publicado: (2021)

New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer
por: Tawfik, Haytham O., et al.
Publicado: (2022)

Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of RAD51A Pre-mRNA in Normal Human CD4(+) T Lymphocytes
por: Gladilina, Yulia A., et al.
Publicado: (2022)

Molecular basis for the distinct divalent cation requirement in the uridylylation of the signal transduction proteins GlnJ and GlnB from Rhodospirillum rubrum
por: Teixeira, Pedro Filipe, et al.
Publicado: (2012)

Global Proteomic Analysis Reveals High Light Intensity Adaptation Strategies and Polyhydroxyalkanoate Production in Rhodospirillum rubrum Cultivated With Acetate as Carbon Source
por: Bayon-Vicente, Guillaume, et al.
Publicado: (2020)

Aerobic-anaerobic transition boosts poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in Rhodospirillum rubrum: the key role of carbon dioxide
por: Godoy, Manuel S., et al.
Publicado: (2023)

L-Lysine α-Oxidase: Enzyme with Anticancer Properties
por: Lukasheva, Elena V., et al.
Publicado: (2021)

THE PHOTOSYNTHETIC APPARATUS OF RHODOSPIRILLUM MOLISCHIANUM
por: Gibbs, Sarah P., et al.
Publicado: (1965)

OBSERVATIONS ON THE STRUCTURE OF RHODOSPIRILLUM MOLISCHIANUM
por: Hickman, Donald D., et al.
Publicado: (1965)

Fed-Batch Cultivations of Rhodospirillum rubrum Under Multiple Nutrient-Limited Growth Conditions on Syngas as a Novel Option to Produce Poly(3-Hydroxybutyrate) (PHB)
por: Karmann, Stephanie, et al.
Publicado: (2019)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Metabolic flexibility revealed in the genome of the cyst-forming α-1 proteobacterium Rhodospirillum centenum
por: Lu, Yih-Kuang, et al.
Publicado: (2010)

No Light, No Germination: Excitation of the Rhodospirillum centenum Photosynthetic Apparatus Is Necessary and Sufficient for Cyst Germination
por: Ashok, Nandhini, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_65aqn5flrjugvas9tcpeog400c