New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound

Phosphatidylinositol 3-kinase α is an attractive target to potentially treat a range of cancers. Herein, we described the evolution of a reported PI3K inhibitor into a moderate PI3Kα inhibitor with a low molecular weight. We used X-ray crystallography to describe the accurate binding mode of the com...

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Detalles Bibliográficos
Autores principales: Yang, Xiuyan, Zhang, Xi, Huang, Min, Song, Kun, Li, Xuefen, Huang, Meilang, Meng, Linghua, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674032/
https://www.ncbi.nlm.nih.gov/pubmed/29109464
http://dx.doi.org/10.1038/s41598-017-15260-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674032/
https://www.ncbi.nlm.nih.gov/pubmed/29109464
http://dx.doi.org/10.1038/s41598-017-15260-5

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