ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export

Mutations in Matrin 3 have recently been linked to ALS, though the mechanism that induces disease in these patients is unknown. To define the protein interactome of wild-type and ALS-linked MATR3 mutations, we performed immunoprecipitation followed by mass spectrometry using NSC-34 cells expressing...

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Detalles Bibliográficos
Autores principales: Boehringer, Ashley, Garcia-Mansfield, Krystine, Singh, Gurkaran, Bakkar, Nadine, Pirrotte, Patrick, Bowser, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674072/
https://www.ncbi.nlm.nih.gov/pubmed/29109432
http://dx.doi.org/10.1038/s41598-017-14924-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674072/
https://www.ncbi.nlm.nih.gov/pubmed/29109432
http://dx.doi.org/10.1038/s41598-017-14924-6

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