A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria

Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently resc...

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Detalles Bibliográficos
Autores principales: Feinberg, Konstantin, Kolaj, Adelaida, Wu, Chen, Grinshtein, Natalie, Krieger, Jonathan R., Moran, Michael F., Rubin, Lee L., Miller, Freda D., Kaplan, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674898/
https://www.ncbi.nlm.nih.gov/pubmed/28877995
http://dx.doi.org/10.1083/jcb.201705085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674898/
https://www.ncbi.nlm.nih.gov/pubmed/28877995
http://dx.doi.org/10.1083/jcb.201705085

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