Allosteric Sensitization of Pro-Apoptotic BAX

BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challen...

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Detalles Bibliográficos
Autores principales: Pritz, Jonathan R., Wachter, Franziska, Lee, Susan, Luccarelli, James, Wales, Thomas E., Cohen, Daniel T., Coote, Paul W., Heffron, Gregory J., Engen, John R., Massefski, Walter, Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675120/
https://www.ncbi.nlm.nih.gov/pubmed/28692068
http://dx.doi.org/10.1038/nchembio.2433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675120/
https://www.ncbi.nlm.nih.gov/pubmed/28692068
http://dx.doi.org/10.1038/nchembio.2433

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