Ubiquitylation-independent activation of Notch signalling by Delta

Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling. These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into...

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Detalles Bibliográficos
Autores principales: Berndt, Nicole, Seib, Ekaterina, Kim, Soya, Troost, Tobias, Lyga, Marvin, Langenbach, Jessica, Haensch, Sebastian, Kalodimou, Konstantina, Delidakis, Christos, Klein, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675594/
https://www.ncbi.nlm.nih.gov/pubmed/28960177
http://dx.doi.org/10.7554/eLife.27346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675594/
https://www.ncbi.nlm.nih.gov/pubmed/28960177
http://dx.doi.org/10.7554/eLife.27346

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