Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine

Ewing sarcoma is a bone and soft tissue sarcoma that occurs in children and young adults. The EWS-FLI1 gene fusion is the driver mutation in most Ewing sarcoma tumors and functions, in part, as an aberrant transcription factor. We recently identified that Ewing sarcoma cells are sensitive to inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Goss, Kelli L, Koppenhafer, Stacia L, Harmoney, Kathryn M, Terry, William W, Gordon, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675612/
https://www.ncbi.nlm.nih.gov/pubmed/29152060
http://dx.doi.org/10.18632/oncotarget.18776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675612/
https://www.ncbi.nlm.nih.gov/pubmed/29152060
http://dx.doi.org/10.18632/oncotarget.18776

Ejemplares similares