Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib

Poly (ADP-ribose) polymerase inhibitors (PARPi) have been developed and tested in a context of combining it with double-stranded (ds) DNA repair defects or inhibitors, as PARP inhibitor impairs single-stranded (ss) DNA break repair, resulting in the activation of the dsDNA break repair machinery. Ra...

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Detalles Bibliográficos
Autores principales: Osoegawa, Atsushi, Gills, Joell J., Kawabata, Shigeru, Dennis, Phillip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675614/
https://www.ncbi.nlm.nih.gov/pubmed/29152062
http://dx.doi.org/10.18632/oncotarget.19667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675614/
https://www.ncbi.nlm.nih.gov/pubmed/29152062
http://dx.doi.org/10.18632/oncotarget.19667

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