Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma

To identify cellular and molecular changes that driver pediatric low grade glioma (PLGG) progression, we analyzed putative cancer stem cells (CSCs) and evaluated key biological changes in a novel and progressive patient-derived orthotopic xenograft (PDOX) mouse model. Flow cytometric analysis of 22...

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Detalles Bibliográficos
Autores principales: Kogiso, Mari, Qi, Lin, Lindsay, Holly, Huang, Yulun, Zhao, Xiumei, Liu, Zhigang, Braun, Frank K., Du, Yuchen, Zhang, Huiyuan, Bae, Goeun, Zhao, Sibo, Injac, Sarah G., Sobieski, Mary, Brunell, David, Mehta, Vidya, Tran, Diep, Murray, Jeffrey, Baxter, Patricia A., Yuan, Xiao-Jun, Su, Jack M., Adesina, Adekunle, Perlaky, Laszlo, Chintagumpala, Murali, Parsons, D. Williams, Lau, Ching C., Stephan, Clifford C., Lu, Xinyan, Li, Xiao-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675646/
https://www.ncbi.nlm.nih.gov/pubmed/29152094
http://dx.doi.org/10.18632/oncotarget.20713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675646/
https://www.ncbi.nlm.nih.gov/pubmed/29152094
http://dx.doi.org/10.18632/oncotarget.20713

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