HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation

In normal colon, claudin-2 expression is restricted to the crypt bottom containing the undifferentiated and proliferative colonocytes. Claudin-2 expression is also upregulated in colorectal cancer (CRC) and promotes carcinogenesis. However, cellular mechanism/s regulated by increased claudin-2 expre...

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Detalles Bibliográficos
Autores principales: Ahmad, Rizwan, Kumar, Balawant, Pan, Kaichao, Dhawan, Punita, Singh, Amar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675667/
https://www.ncbi.nlm.nih.gov/pubmed/29152115
http://dx.doi.org/10.18632/oncotarget.21190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675667/
https://www.ncbi.nlm.nih.gov/pubmed/29152115
http://dx.doi.org/10.18632/oncotarget.21190

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