Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α

We demonstrated sensitization for chemotherapy by Smac mimetic (SM) LCL161, a potent antagonist of inhibitor of apoptosis proteins (IAP), in neuroblastoma (NB). Vinca alkaloids, particularly vincristine (VCR), displayed the strongest impact on inhibition of proliferation and apoptosis induction in c...

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Detalles Bibliográficos
Autores principales: Langemann, Doerte, Trochimiuk, Magdalena, Appl, Birgit, Hundsdoerfer, Patrick, Reinshagen, Konrad, Eschenburg, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675670/
https://www.ncbi.nlm.nih.gov/pubmed/29152118
http://dx.doi.org/10.18632/oncotarget.21193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675670/
https://www.ncbi.nlm.nih.gov/pubmed/29152118
http://dx.doi.org/10.18632/oncotarget.21193

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