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Sensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α

We demonstrated sensitization for chemotherapy by Smac mimetic (SM) LCL161, a potent antagonist of inhibitor of apoptosis proteins (IAP), in neuroblastoma (NB). Vinca alkaloids, particularly vincristine (VCR), displayed the strongest impact on inhibition of proliferation and apoptosis induction in c...

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Detalles Bibliográficos
Autores principales:	Langemann, Doerte, Trochimiuk, Magdalena, Appl, Birgit, Hundsdoerfer, Patrick, Reinshagen, Konrad, Eschenburg, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675670/ https://www.ncbi.nlm.nih.gov/pubmed/29152118 http://dx.doi.org/10.18632/oncotarget.21193

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