Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells

The transcription factor hypoxia-inducible factor-1 (HIF-1) consists of oxygen-sensitive HIF-1α and constitutive HIF-1β. HIF-1α is undetectable in normal cells, but cancer cells frequently express HIF-1α to support their growth, angiogenesis, and high glycolysis (also known as the Warburg effect). T...

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Detalles Bibliográficos
Autores principales: Hu, Lijuan, Cui, Rui, Liu, Hongyi, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675689/
https://www.ncbi.nlm.nih.gov/pubmed/29152137
http://dx.doi.org/10.18632/oncotarget.21330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675689/
https://www.ncbi.nlm.nih.gov/pubmed/29152137
http://dx.doi.org/10.18632/oncotarget.21330

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