Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs

Rapid progress has been made toward small interfering RNA (siRNA)-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found...

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Detalles Bibliográficos
Autores principales: Song, Xinyun, Wang, Xiaoxia, Ma, Yuan, Liang, Zicai, Yang, Zhenjun, Cao, Huiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675723/
https://www.ncbi.nlm.nih.gov/pubmed/29246303
http://dx.doi.org/10.1016/j.omtn.2017.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675723/
https://www.ncbi.nlm.nih.gov/pubmed/29246303
http://dx.doi.org/10.1016/j.omtn.2017.10.003

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