Cargando…
Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs
Rapid progress has been made toward small interfering RNA (siRNA)-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675723/ https://www.ncbi.nlm.nih.gov/pubmed/29246303 http://dx.doi.org/10.1016/j.omtn.2017.10.003 |