Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span

The shelterin complex protects telomeres by preventing them from being degraded and recognized as double‐strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We previously showed that TRF1 deficiency in the context of d...

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Detalles Bibliográficos
Autores principales: Derevyanko, Aksinya, Whittemore, Kurt, Schneider, Ralph P., Jiménez, Verónica, Bosch, Fàtima, Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676056/
https://www.ncbi.nlm.nih.gov/pubmed/28944611
http://dx.doi.org/10.1111/acel.12677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676056/
https://www.ncbi.nlm.nih.gov/pubmed/28944611
http://dx.doi.org/10.1111/acel.12677

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